Laboratoire de Neuroimmunologie de l'Asthme - Publications

The effects of extracellular purines and pyrimidines on human airway smooth muscle cells.

Sun, 11 Jun 2006 15:13:04 -0400

Related Articles The effects of extracellular purines and pyrimidines on human airway smooth muscle cells. J Pharmacol Exp Ther. 2005 Nov;315(2):941-8

Role of airway eosinophilia and eosinophil activation in Sephadex-induced inflammation.

Sun, 11 Jun 2006 15:13:01 -0400

Related Articles Role of airway eosinophilia and eosinophil activation in Sephadex-induced inflammation. Inflammation. 2004 Aug;28(4):195-206 Authors: Maghni K, Nantel F, Lanoue C, Cloutier S, Cristol JP, Cadieux A, Sirois P The effects of an intravenous injection of Sephadex beads on lung eosinophil infiltration and eosinophil peroxydase activity and its relationship to bronchial hyperresponsiveness was examined in guinea pigs. This Sephadex beads injection led to blood, lung and airway eosinophilia in association with bronchial hyperresponsiveness. Histologic examination of the lower bronchus indicated that the eosinophil number increased markedly in the mucosa and submucosa. In addition, the eosinophils surrounding the bronchioles 1 day after the Sephadex injection migrated further in airway submucosa and mucosa 7 and 14 days after. Moreover, the bronchial hyperresponsiveness is observed without histologic evidence of airway epithelium damage. Therefore, the bronchial hyperresponsiveness seems to be more related to the eosinophil infiltration in the airway epithelium and possibly eosinophil activation rather than to the eosinophil number recovered in the BAL fluid. We conclude that the maintenance of hyperresponsiveness state could be associated with the persistence of blood and airway eosinophilia.

CCR3 expression and function in asthmatic airway smooth muscle cells.

Sun, 11 Jun 2006 15:13:01 -0400

Related Articles CCR3 expression and function in asthmatic airway smooth muscle cells. J Immunol. 2005 Aug 15;175(4):2702-8

Conjugates of ovalbumin and monomethoxypolyethylene glycol abolish late allergic responses and decrease IL-4 and IL-5 mRNA expre

Sun, 11 Jun 2006 15:12:58 -0400

Related Articles Conjugates of ovalbumin and monomethoxypolyethylene glycol abolish late allergic responses and decrease IL-4 and IL-5 mRNA expression in the rat. Pulm Pharmacol Ther. 2003;16(6):361-9 Authors: Lavoie JP, Maghni K, Taha R, Yang XX, Lang GM, Sehon AH, Hamid QA, Martin JG The purpose of this study was to test the therapeutic potential of monomethoxypolyethylene glycol (mPEG) conjugated-allergen using a rodent model of allergic asthma. Previously, this conjugate has been shown to possess the dual capacity of inducing long-term ovalbumin (OA)-specific suppression of the antibody response and inactivating rat mast cells that have been sensitized with murine IgE to OA. Ovalbumin sensitized and challenged Brown Norway rats were studied. Fourteen days after sensitization, a test group of six rats received mPEG-OA solution intratracheally and were challenged 30 min later with aerosolized OA. Another group of seven sensitized rats was similarly challenged with OA 30 min after intratracheal administration of normal saline. A group of six sensitized rats received mPEG-OA solution intratracheally but were challenged with normal saline. Another group of seven sensitized rats received mPEG-BSA solution intratracheally and were challenged 30 min later with aerosolized OA. A final group of five unsensitized rats were neither challenged nor medicated intratracheally. Pulmonary resistance was measured before and for 8 h following inhalation challenge. mPEG-OA treatment had an inhibitory effect on the allergic late airway response, but the early response was not significantly altered. Both mPEG-OA and mPEG-BSA reduced the total cells, eosinophils and neutrophils, in bronchoalveolar lavage and decreased the expression of IL-4, IL-5 and IFN-gamma mRNA. In conclusion, mPEG-OA can prevent the development of allergen-induced late airway responses and reduce airway Th2-type cytokine expression whereas mPEG conjugated to an irrelevant antigen (BSA) is anti-inflammatory but does not affect the late response.

IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle.

Sun, 11 Jun 2006 15:12:58 -0400

Related Articles IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle.

Airway inflammation after cessation of exposure to agents causing occupational asthma.

Sun, 11 Jun 2006 15:12:55 -0400

Related Articles Airway inflammation after cessation of exposure to agents causing occupational asthma. Am J Respir Crit Care Med. 2004 Feb 1;169(3):367-72

The effects of CD8+gammadelta T cells on late allergic airway responses and airway inflammation in rats.

Sun, 11 Jun 2006 15:12:55 -0400

Related Articles The effects of CD8+gammadelta T cells on late allergic airway responses and airway inflammation in rats. J Allergy Clin Immunol. 2003 Sep;112(3):547-55

Time course of airway mechanics of the (+)insert myosin isoform knockout mouse.

Sun, 11 Jun 2006 15:12:52 -0400

Related Articles Time course of airway mechanics of the (+)insert myosin isoform knockout mouse. Am J Respir Cell Mol Biol. 2004 Mar;30(3):326-32

Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5,

Sun, 11 Jun 2006 15:12:52 -0400

Related Articles Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13. J Allergy Clin Immunol. 2003 May;111(5):1049-61

Chlorine-induced injury to the airways in mice.

Sun, 11 Jun 2006 15:12:49 -0400

Related Articles Chlorine-induced injury to the airways in mice. Am J Respir Crit Care Med. 2003 Sep 1;168(5):568-74 Authors: Martin JG, Campbell HR, Iijima H, Gautrin D, Malo JL, Eidelman DH, Hamid Q, Maghni K

Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and ne

Sun, 11 Jun 2006 15:12:49 -0400

Related Articles Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils. Intensive Care Med. 2003 Jun;29(6):923-8

Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-a gene: regulation b

Sun, 11 Jun 2006 15:12:46 -0400

Related Articles Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-a gene: regulation by passive sensitization.

Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse.

Sun, 11 Jun 2006 15:12:46 -0400

Related Articles Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse. Am J Respir Cell Mol Biol. 2003 Jan;28(1):25-32

Effects of extracellular triphosphate nucleotides and nucleosides on airway smooth muscle cell proliferation.

Sun, 11 Jun 2006 15:12:43 -0400

Related Articles Effects of extracellular triphosphate nucleotides and nucleosides on airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol. 2002 Dec;27(6):732-8

The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat.

Sun, 11 Jun 2006 15:12:43 -0400

Related Articles The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat. J Immunol. 2002 Oct 1;169(7):3963-9